The present study was designed to evaluate the toxic effects of Doxorubicin on sero-biohemical parameters in Wistar rats and their amelioration. Group1- Control, Group 2 - Doxorubicin – Toxic control given @ 2mg / kg body wt. by intravenous injection for 5 days followed by weekly once for 2 weeks, Group 3 - Pre treatment with ascorbic acid @ 500mg / kg feed by enteral route for 7 days followed by intravenous injection of Doxorubicin as mentioned in group 2. Ascorbic acid supplementation was continued during these 19 days, Group 4 - Pre treatment with Spirulina @ 1000mg / kg feed by enteral route for 7 days followed by intravenous injection of Doxorubicin as mentioned in group 2. Supplementation of Spirulina was continued during these 19 days. 100% mortality was recorded in group 2 on third day after 5th dose of doxorubicin and in group 3, 50% mortality was recorded. Hence, the experiment was terminated on day 8. The biochemical assays showed significant (P<0.05) increase in creatinine phosphokinase (CPK), lactate dehydrogenase (LDH), cardiac troponins (cTn), aspartate transaminase (AST), alanine transaminase (ALT), creatinine and blood urea nitrogen (BUN) levels in Doxorubicin treated rats. There was considerable amelioration in ascorbic acid and spirulina fed groups.
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